Post Number: 1076
|Posted on Wednesday, December 24, 2008 - 04:50 am: |
This is an interesting research, as it may fit in the whole idea of ECGM ( extended central governor model )
Some may remember the FaCT ECGM , where we named one of them the glucostat. A potential senosr , who controls the level of glucose in the system and the "feed back " will allow for release of Insulin or glucagon, or as in some ideas , the change of searching for proteins to "feed" the brain with glucose..
Now in some papers I showed here many month ago , the russian idea on respiratory intervention ( Frolow) uses hypercapnai based on ergogenic breathing to "treat " Alzheimers and brain hypo perfusion problems .
How: They base their old ideas on the impact CO2 has in increasing vasodilatation ( blood flow )
So they use a hypoxic . hypercapnaic respiratory technique, as well a very simple device to create a permissive pCO2 level and a SpO2 of 90 - 92 % to treat and increase brain blood circulation.
This article could be in some way a connection to the russian idea on treatments , just from a different point of view.
The result can have some interesting applications for sport and traiing to use permissivie Hypercapnia to creat some very specific stimmulation.
There is an interesting combination of hypercapnia and left ventricular elsaticity change, where they tested the elasticity under higher pCO2 levels and found out , that the EF % would actually drop under stress, if the pCO2 was increasing.
So I will do over the next few days some permissive hypercapnia and assess the EF % with the physio flow , to see, whether there is a trend in one or the other direction.
Here the summary from CBC medical news. :
"Scientists have found that when the brain is slowly starved of glucose over time, some forms of Alzheimer's disease may result.
Researchers used human and mice brains to study how a reduction in blood flow deprives the brain of energy. The chronic starvation eventually leads to sticky clumps of a protein linked to Alzheimer's, the leading cause of dementia in the elderly, they found.
"This finding is significant because it suggests that improving blood flow to the brain might be an effective therapeutic approach to prevent or treat Alzheimer's," said the study's lead author, Robert Vassar, a professor of cell and molecular biology at Northwestern University in Chicago.
It's possible that preventive strategies such as getting exercise, reducing cholesterol and managing blood pressure could help prevent Alzheimer's by improving blood flow to the brain.
"If people start early enough, maybe they can dodge the bullet," Vassar added in a release.
In the Dec. 26 issue of the journal Neuron, Vasser and his colleagues said they discovered a protein called elF2alpha that is changed when the brain fails to get enough energy in the form of glucose.
If this is true some specific respiratory exercises we do with our prototype may be a very cheap and interesting alternative as a part of senior exercises to build into a circuit workout.